Mannose Binding Lectin
Also known as: MBL
Use
Mannose-binding protein, a component of the innate immune system, binds mannose residues on various microorganisms, triggering the complement pathway for opsonization. It's also an acute phase reactant produced by the liver. Abnormal mannose-binding protein levels may lead to recurrent infections without abnormalities in the major immune system arms. Abnormal concentrations have been associated with infectious diseases like tuberculosis and hepatitis B, as well as autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosus.
Special Instructions
Not provided.
Limitations
Abnormal mannose-binding protein levels may be found in patients with various infectious or autoimmune disorders, but this test is not FDA cleared or approved, and performance characteristics were determined by ARUP Laboratories. Utilized for clinical purposes in a CLIA-certified laboratory.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
Mannose-binding protein
Protein
LOINC Codes
- 30152-3 - Mannose-BP Ser-mCnc
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Frozen. Also acceptable: Refrigerated if maintained at temperature for less than 7 days.
Causes for Rejection
Nonserum, contaminated, or heat-inactivated specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 7 days |
| Frozen | 30 days |
Other tests from different labs that may be relevant