MET Exon 14 Deletion Analysis by PCR
Also known as: MET 14
Use
The MET Exon 14 Deletion Analysis by PCR test is designed to detect deletions in exon 14 of the MET gene, which are associated with cancer. Such genetic alterations can lead to constitutive activation of the MET receptor, contributing to tumor growth and progression. Identification of this mutation can help in tailoring personalized treatment strategies and determining eligibility for MET-targeted therapies.
Special Instructions
Not provided.
Limitations
The test is not performed at ARUP and involves separate submission when multiple tests are ordered. It only detects deletions within exon 14 of the MET gene and may not identify other alterations or mutations outside this region. The methodology may not be suitable for all specimen types or conditions of fixation.
Methodology
PCR-based (Real-Time Polymerase Chain Reaction)
Biomarkers
MET
Gene
LOINC Codes
- 11502-2 - Laboratory report
Result Turnaround Time
14-17 days
Related Documents
For more information, please review the documents below
Specimen
Tumor Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Tissue block or 1 H&E slide plus 10 unstained (5-micron thick), positively charged slides
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Transport in a tissue transport kit (ARUP supply #47808).
Storage Instructions
Protect from extreme temperatures.
Causes for Rejection
Fixed in any other fixative other than 10% neutral buffered formalin.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant