Mitotane, Serum or Plasma
Also known as: MITOT SP
Use
The Mitotane, Serum or Plasma test is primarily used for therapeutic drug monitoring. It assists in optimizing drug therapy by measuring the concentration of mitotane, a medication used in the treatment of adrenocortical carcinoma, in patients' serum or plasma. Regular monitoring ensures that therapeutic levels are maintained while preventing potential toxicity, especially given mitotane's narrow therapeutic window.
Special Instructions
This test requires separate specimens to be submitted when multiple tests are ordered, as it is performed by a non-ARUP laboratory. Patients should be aware that the test is not conducted at ARUP, and appropriate logistics for specimen collection and transportation should be arranged accordingly.
Limitations
The test utilizes quantitative gas chromatography, performed by NMS Labs, to measure mitotane levels. It has not been cleared or approved by the FDA, and there may be limits in sensitivity and specificity inherent to the methodology. Additionally, separator tubes are not acceptable for specimen collection. Stability constraints must be considered, with a noted stability of 2 weeks at ambient and refrigerated temperatures, and 28 days if frozen.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 13626-7
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated. Also acceptable: Room temperature or frozen.
Causes for Rejection
Separator tubes.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 weeks |
| Refrigerated | 2 weeks |
| Frozen | 28 days |