Myelin Basic Protein
Also known as: MBP
Use
Myelin Basic Protein (MBP) test is used to quantify the protein levels in cerebrospinal fluid (CSF) and may provide insights into various neurological conditions. Elevated levels of MBP in CSF can indicate demyelination, which is associated with a variety of neurological disorders, including multiple sclerosis, traumatic brain injury, and other neurodegenerative diseases.
Special Instructions
This test is not recommended for the workup of suspected multiple sclerosis. The preferred test for such cases is the Oligoclonal Band Profile (Test Code: 0080440). Ensure CSF samples are free from blood contamination to avoid falsely elevated levels of MBP.
Limitations
The test has not been cleared or approved by the US Food and Drug Administration (FDA). It is intended for clinical purposes and conducted in a CLIA-certified laboratory. Analytical performance of the test may be affected by hemolysis, leading to falsely elevated MBP levels.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 2638-5
- 2638-5
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP standard transport tube
Collection Instructions
Avoid hemolysis by centrifuging bloody CSF samples and separating supernatant before freezing.
Storage Instructions
Store frozen. Avoid freeze/thaw cycles.
Causes for Rejection
Hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 3 weeks |