Neuron Specific Enolase, Serum

Casandra

Casandra Test Code AR05061Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3004312CPT Code 86316

Neuron Specific Enolase, Serum

Also known as: NSE S

Clinical Use

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Use

The Neuron Specific Enolase, Serum test is used to detect neuron specific enolase, which may serve as a tumor marker in the evaluation of neuroendocrine tumors. Elevated levels of neuron specific enolase could indicate the presence of neuroendocrine tumors, making it a useful tool in the clinical assessment of diseases such as neuroblastoma. However, results obtained through different assay methods or kits are not interchangeable, and elevated levels must be interpreted with caution considering other clinical findings.

Special Instructions

It's important to ensure that the serum has clotted completely at room temperature and that it is separated from cells as soon as possible or within two hours of collection. Transfer of 1 mL serum to an ARUP Standard Transport Tube is required, with a minimum volume of 0.5 mL. Use of a serum separator tube is recommended, although a plain red tube is acceptable as well.

Limitations

This test is performed using the BRAHMS NSE Kryptor Immunoassay, and results obtained cannot be directly compared with those from other assay methods or kits. Additionally, while neuron specific enolase can be a useful marker, it cannot be used as absolute evidence of the presence or absence of malignant disease. Certain conditions, such as hemolysis of the specimen, can falsely elevate NSE levels as the enzyme is expressed in red blood cells.

Test Details

New York Approved