Nickel, Urine
Use
Measurement of nickel in urine is used to assess exposure to nickel. This test is not recommended for asymptomatic individuals or those with a low likelihood of exposure. Elevated levels might suggest contamination from skin or the collection process, especially if non-certified trace element-free containers are used.
Special Instructions
Patients should discontinue nutritional supplements, vitamins, minerals, and nonessential medications under physician guidance, and abstain from iodine-based medications or contrast agents for at least a month before collection. The test requires 24-hour or random urine in a plastic container, with refrigeration recommended if tested within 14 days. Volume and collection interval should be recorded.
Limitations
Results can be contaminated by non-trace element-free containers, blood, fecal material, or urine collected within 48 hours of gadolinium-containing contrast media administration. Acid-preserved urine is unacceptable. Elevated results might be due to contamination rather than true nickel exposure.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 35674-1
- 2162-6
- 29936-2
- 30933-6
- 5705-9
- 19153-6
- 30211-7
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
Not provided
Minimum Volume
1 mL
Container
ARUP Trace Element-Free Transport Tubes
Collection Instructions
24-hour or random urine collection. Specimen must be collected in a plastic container. Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes.
Patient Preparation
Abstain from iodine-containing drugs or contrast a month prior. Discontinue nonessential medications and supplements upon advice.
Storage Instructions
Refrigerated transport recommended. Room temperature and frozen also acceptable.
Causes for Rejection
Urine collected within 48 hours of gadolinium-containing contrast media. Acid-preserved urine, and specimens contaminated with blood or fecal material. Non-trace element-free transport tubes are unacceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | 1 year |