Nortriptyline
Also known as: NORT HPLC
Use
The Nortriptyline test is used to optimize dosing and monitor patient adherence. It helps in maintaining therapeutic concentrations, which are necessary for the effectiveness of the medication. Monitoring nortriptyline levels can prevent toxic concentrations that lead to adverse effects such as anticholinergic effects, cardiac abnormalities, and seizures.
Special Instructions
If amitriptyline is administered alongside nortriptyline, it is recommended to order the Amitriptyline and Nortriptyline test with ARUP test code 0090158. Specimen collection should be predose (trough) at a steady-state concentration.
Limitations
This test has been developed and its performance characteristics determined by ARUP Laboratories. It is a laboratory developed test (LDT) and has not been cleared or approved by the United States Food and Drug Administration (FDA). It is intended for clinical purposes and performed in a CLIA certified laboratory.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 3872-9
- 3872-9
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum or plasma from cells within 2 hours of collection.
Patient Preparation
Predose (trough) draw at steady-state concentration.
Storage Instructions
Refrigerated.
Causes for Rejection
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 5 days |
| Refrigerated | 2 weeks |
| Frozen | 6 months |