NR4A3 Rearrangement by FISH

Casandra

Casandra Test Code AR66761Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3006357CPT Code 88366

NR4A3 Rearrangement by FISH

Also known as: NR4A3 FISH

Clinical Use

Order Test

Use

The NR4A3 Rearrangement by FISH test is designed to detect rearrangements involving the NR4A3 gene. This testing is useful for diagnosing extraskeletal myxoid chondrosarcoma and salivary acinic cell carcinoma. The identification of a rearrangement of the NR4A3 gene locus can assist in the confirmation of these diagnoses. Furthermore, NR4A3 rearrangements may be detected rarely in other tumors, making this test a valuable diagnostic tool for identifying NR4A3 rearranged tumors at an early stage.

Special Instructions

Include the surgical pathology report with your specimen submission. If multiple specimens are sent for analysis, they must be accompanied by a comment requesting a pathologist to choose the most appropriate specimen for testing, or by individual orders for each submitted sample. Additional fees may apply for pathologist specimen selection.

Limitations

This test detects rearrangements involving the NR4A3 gene but does not identify any specific partner genes involved in the rearrangement. Only abnormal signal patterns presented in 25 percent or more of the tumor cells evaluated are considered a positive result. The test does not detect cryptic rearrangements and has not been cleared or approved by the FDA. Correlation with histopathological and clinical findings is essential for a comprehensive interpretation.

Test Details

New York Approved