NTRK Fusion Panel by Next Generation Sequencing
Also known as: NTRK PAN
Use
The NTRK Fusion Panel by Next Generation Sequencing is designed for the detection of NTRK gene fusions, which are critical diagnostic and therapeutic biomarkers in various cancers such as thyroid and breast cancer. Detecting these fusions can provide important information for patient management, including prognostic implications and potential eligibility for targeted therapies like TRK inhibitors.
Special Instructions
Formal collection and handling requirements must be strictly followed. Tumor tissue must be formalin-fixed and paraffin-embedded, and specific slide types are required. Coordination with ARUP for specimen transport is needed, with an emphasis on protecting samples from extreme temperatures.
Limitations
The test is not performed at ARUP Laboratories and is sent out to a non-ARUP laboratory for analysis. Limitations exist if the specimen is not properly fixed or embedded, potentially affecting the accuracy of fusion detection. Additionally, not all NTRK fusions may be detected due to assay sensitivity constraints and tissue quality.
New York Approved
Methodology
NGS
Biomarkers
LOINC Codes
- 11502-2
Result Turnaround Time
21-24 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
5 slides
Container
Tissue block or 1 H&E slide plus 10 unstained (5-micron thick), positively charged slides in a tissue transport kit
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from extreme temperatures.
Storage Instructions
Refrigerated. Also acceptable: Ambient.
Causes for Rejection
Fixed in any other fixative other than 10% neutral buffered formalin.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |