Pharmacogenetics Panel: Psychotropics
Also known as: PGX PSYCH
Use
This test is used to assess genetic risk of abnormal drug metabolism for drugs metabolized by various genes such as ANKK1, COMT, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, DRD2, GRIK4, HTR2A, HTR2C, MTHFR, OPRM1, and UGT2B15. It may aid in drug selection and dose planning for many drugs, including those relevant to psychiatry such as psychostimulants, antidepressants, antipsychotics, and anxiolytics.
Special Instructions
Not provided.
Limitations
Only the targeted variants will be detected by this panel, and assumptions about phase and content are made to assign alleles. The test does not detect non-genetic factors that may influence drug response. Diagnostic errors can occur due to rare sequence variations. A combination of the CYP2D6*5 (gene deletion) and a CYP2D6 gene duplication cannot be specifically identified.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 94415-7 - OPRM1 c.118A>G Geno Bld/T
- 79715-9 - CYP2D6 gene prod met act imp Bld/T-Imp
- 79716-7 - CYP2C9 gene prod met act imp Bld/T-Imp
- 79714-2 - CYP2C19 gene prod met act imp Bld/T-Imp
- 46724-1 - CYP2C9 allele Geno Bld/T
- 57132-3 - CYP2C19 allele Geno Bld/T
- 40425-1 - CYP2D6 allele Geno Bld/T
- 81139-8 - CYP3A4 allele Geno Bld/T
- 81140-6 - CYP3A5 allele Geno Bld/T
- 72882-4 - CYP2B6 allele Geno Bld/T
- 79720-9 - CYP2B6 gene prod met act imp Bld/T-Imp
- 79717-5 - CYP3A5 gene prod met act imp Bld/T-Imp
- 66746-9 - Specimen type
- 94418-1 - UGT2B15 c.253G>T Geno Bld/T
- 94402-5 - ANKK1 c.2137G>A Geno Bld/T
- 74511-7 - COMT c.1947G>A Geno Bld/T
- 94411-6 - DRD2 c.-585A>G Geno Bld/T
- 94413-2 - GRIK4 c.83-10039T>C Geno Bld/T
- 75726-0 - HTR2A c.-1438G>A Bld/T Ql
- 93190-7 - HTR2A c.614-2211T>C Geno Bld/T
- 75732-8 - HTR2C c.-759C>T Bld/T Ql
- 28005-7 - MTHFR c.677C>T Geno Bld/T
- 28060-2 - MTHFR c.1298A>C Geno Bld/T
- 81259-4 - Prob assoc phenotype
- 50398-7 - Narrative diagnostic report-Imp
- 11526-1 - Pathology study
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
1 mL
Container
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma or serum, specimens collected in sodium heparin or lithium heparin, and frozen specimens in glass collection tubes.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 1 week |
| Frozen | 1 month |
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