Phenobarbital, Total/Unbound/Bound, S/P
Also known as: PHENOBAR
Use
This test is used to optimize drug therapy and monitor patient adherence by measuring the levels of phenobarbital. It assesses the total, unbound (free), and bound concentrations of phenobarbital in serum or plasma, aiding in the management of anticonvulsant therapy and ensuring appropriate therapeutic levels are maintained.
Special Instructions
Not provided.
Limitations
The test utilizes High Performance Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), which is a selective and sensitive method for measuring phenobarbital. However, it has not been cleared or approved by the US Food and Drug Administration. The test cannot be performed using separator tubes, which are considered unacceptable conditions. Bound phenobarbital is calculated by subtracting the unbound fraction from the total concentration, and errors in these measurements may affect the accuracy of the bound phenobarbital calculation.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
Phenobarbital, Bound
AnalytePhenobarbital, Total
AnalytePhenobarbital, Unbound
Analyte
LOINC Codes
- 3948-7 - Phenobarb SerPl-mCnc
- 3951-1 - PHENobarb Free SerPl-mCnc
Result Turnaround Time
8-11 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.9 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate from cells ASAP or within 2 hours of collection.
Causes for Rejection
Separator tubes.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 3 months |
| Refrigerated | 3 months |
| Frozen | 18 months |
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