Phosphatidylethanol (PEth), Whole Blood, Quantitative
Also known as: PETH
Use
Phosphatidylethanol (PEth) is a direct alcohol biomarker formed in the presence of ethanol, phospholipase D, and phosphatidylcholine. PEth is incorporated into the phospholipid membrane of red blood cells and has a half-life of 4-10 days. It provides a window of detection lasting 2-4 weeks, or longer in individuals who consume alcohol excessively or chronically. The predominant PEth homologues, such as PEth 16:0/18:1 (POPEth) and PEth 16:0/18:2 (PLPEth), account for the majority of total PEth homologues. Serial monitoring aids in tracking alcohol abstinence, while PEth results should be interpreted alongside patient clinical and behavioral history.
Special Instructions
Patients with advanced liver disease may have falsely elevated PEth concentrations. Collection requires specific tubes, and unsuitable substitutions could result in rejected samples.
Limitations
PEth results are affected by individual's alcohol consumption history and are susceptible to false elevations in patients with advanced liver disease. The window of detection may vary depending on the frequency and volume of alcohol intake. Accurate interpretation requires comprehensive review of the patient's clinical context and behavioral history alongside PEth levels.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 97606-8
- 97607-6
- 11502-2
- 77202-0
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
1 mL
Minimum Volume
0.5 mL
Container
Lavender (K2 or K3EDTA), pink (K2EDTA), dark green (lithium heparin), or gray (potassium oxalate)
Causes for Rejection
Gel separator tubes, plain red, light blue (citrate), or yellow (SPS or ACD solution)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 3 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month (-20 degrees C) |