Phosphatidylserine Antibodies, IgG, IgM, and IgA
Also known as: PHOS AB
Use
IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and an increased risk for obstetric antiphospholipid syndrome (APS). In some cases, the presence of these antibodies may indicate possible APS or systemic lupus erythematosus (SLE). Clinical correlation is recommended, especially in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin, and/or beta2 glycoprotein antibodies. It is necessary to interpret the results in conjunction with APS-specific clinical manifestations and other phospholipid antibody tests.
Special Instructions
The isolated presence of IgM or IgG antibodies to aPS has questionable clinical significance for APS and/or SLE. Positive results should be confirmed with repeat testing using two or more specimens collected at least 12 weeks apart to demonstrate antibody persistence.
Limitations
This test is not recommended as a primary panel for diagnosing antiphospholipid syndrome (APS). It is advised as a secondary test for seronegative APS. Results should not be used alone for diagnosis and must be correlated with clinical findings and other specific criteria for phospholipid antibody tests.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 32031-7
- 32032-5
- 32033-3
- 32032-5
- 32033-3
- 32031-7
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.25 mL
Container
Serum separator tube
Storage Instructions
Refrigerated
Causes for Rejection
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |