Platelet Aggregation Studies
Also known as: PLTAG
Use
The Platelet Aggregation Studies test is used to evaluate patients with suspected platelet dysfunction, which may be inherited or acquired. It includes ristocetin-induced platelet aggregation (RIPA), and is useful in distinguishing between type 2 subtypes in patients diagnosed with von Willebrand disease when ordered in consultation with a coagulation specialist. The test aids in assessing abnormalities in platelet function that could be linked to various clinical conditions such as Noonan syndrome, storage pool disease, or medication effects like aspirin usage.
Special Instructions
A patient history form must be submitted and approved prior to scheduling specimen collection. Testing is to be scheduled and performed at the ARUP Family Health Clinic. The test is not New York state approved and requires a Non-Permitted Laboratory Request Form submission to the NYDOH if testing is needed in New York.
Limitations
The test is not an initial diagnostic tool for von Willebrand disease and should not be used as such. Specimen stability is critical, with the sample only being stable for 4 hours at room temperature. Samples must be collected and processed by the ARUP Hemostasis/Thrombosis Lab, and any delay or improper handling could compromise the results. Abnormalities found in the test can be due to several factors including medication effects, storage pool disease, or intrinsic platelet abnormalities, and should be correlated clinically for interpretation.
Methodology
Cell-based / Cytometry
Biomarkers
LOINC Codes
- 21027-8
- 24377-4
- 24379-0
- 24380-8
- 24381-6
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Specimen collection is scheduled and performed at ARUP clinics. Specific instructions from the ARUP Hemostasis/Thrombosis lab accompany the Patient History for Platelet Aggregation Studies form.
Storage Instructions
Store and transport at critical room temperature.
Causes for Rejection
Specimens not scheduled by ARUP lab and not collected by ARUP.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | Unacceptable |