Platelet Aggregation Studies

Also known as: PLTAG

Clinical Use

Use

The Platelet Aggregation Studies test is used to evaluate patients with suspected platelet dysfunction, which may be inherited or acquired. It includes ristocetin-induced platelet aggregation (RIPA), and is useful in distinguishing between type 2 subtypes in patients diagnosed with von Willebrand disease when ordered in consultation with a coagulation specialist. The test aids in assessing abnormalities in platelet function that could be linked to various clinical conditions such as Noonan syndrome, storage pool disease, or medication effects like aspirin usage.

Special Instructions

Not provided.

Limitations

The test is not an initial diagnostic tool for von Willebrand disease and should not be used as such. Specimen stability is critical, with the sample only being stable for 4 hours at room temperature. Samples must be collected and processed by the ARUP Hemostasis/Thrombosis Lab, and any delay or improper handling could compromise the results. Abnormalities found in the test can be due to several factors including medication effects, storage pool disease, or intrinsic platelet abnormalities, and should be correlated clinically for interpretation.

Test Details

Methodology

Cell-based / Cytometry

Biomarkers

Platelet Aggregation - AAPlatelet Aggregation - ADPPlatelet Aggregation - CollagenPlatelet Aggregation - Ristocetin

LOINC Codes

Order Codes

21027-8 - PA PPP-Imp
24377-4 - Platelet aggr int PRP Adenosine diphosphate induced-Imp
24379-0 - Platelet aggr int PRP Collagen induced-Imp
24380-8 - Platelet aggr int PRP Ristocetin induced-Imp
24381-6 - Platelet aggr int PRP Arachidonate induced-Imp

Result Turnaround Time

1-2 days

Specimen

Whole Blood

Volume

Not provided

Minimum Volume

Not provided

Collection Instructions

Specimen collection is scheduled and performed at ARUP clinics. Specific instructions from the ARUP Hemostasis/Thrombosis lab accompany the Patient History for Platelet Aggregation Studies form.