Platelet Antigen Genotyping Panel, Fetal
Also known as: HPAGENO FE
Use
The Platelet Antigen Genotyping Panel, Fetal is used for fetal genotyping to assess the risk of alloimmune thrombocytopenia. This condition, known as perinatal alloimmune thrombocytopenia (PAT), can cause spontaneous fetal intracranial bleeding in severe cases and carries a risk of fetal death. The test is critical for managing pregnancies at risk for PAT, particularly when the mother is homozygous for the less common 'b' HPA allele and has antibodies to the common 'a' allele. It provides essential genotypic information to guide clinical decisions for affected pregnancies.
Special Instructions
Not provided.
Limitations
This test may yield false-negative results if maternal cell contamination occurs in the amniotic fluid specimen. Diagnostic errors can occur due to rare sequence variations, and the performance of this test has not been cleared or approved by the US Food and Drug Administration. It is performed in a CLIA-certified laboratory intended for clinical purposes. The analytic sensitivity and specificity are both 99 percent, but clinical sensitivity is variable and depends on ethnicity.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 59266-7 - Maternal Cell Contam Spec
- 66746-9 - Specimen type
Result Turnaround Time
7-14 days
Related Documents
For more information, please review the documents below
Specimen
Amniotic Fluid
Volume
10 mL
Minimum Volume
5 mL
Container
sterile container
Storage Instructions
CRITICAL ROOM TEMPERATURE. Must be received within 48 hours of shipment due to lability of cells.
Causes for Rejection
Frozen specimens in glass collection tubes.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
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