Platelet Antigen Genotyping Panel, Fetal

Casandra

Casandra Test Code AR79232Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3016673CPT Codes 81105, 81106, 81107, 81108, 81109, 81110, 81112, 81265

Platelet Antigen Genotyping Panel, Fetal

Also known as: HPAGENO FE

Clinical Use

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Use

The Platelet Antigen Genotyping Panel, Fetal is used for fetal genotyping to assess the risk of alloimmune thrombocytopenia. This condition, known as perinatal alloimmune thrombocytopenia (PAT), can cause spontaneous fetal intracranial bleeding in severe cases and carries a risk of fetal death. The test is critical for managing pregnancies at risk for PAT, particularly when the mother is homozygous for the less common 'b' HPA allele and has antibodies to the common 'a' allele. It provides essential genotypic information to guide clinical decisions for affected pregnancies.

Special Instructions

Informed Consent for Genetic Testing is required for patients from New York. In addition, if clients are unable to culture, they should order the Cytogenetics Grow and Send test in addition to this one, allowing ARUP to culture upon receipt. This test does not include antibody identification and requires coordination with the Platelet Antibody Identification Panel (3017737) for complete assessment.

Limitations

This test may yield false-negative results if maternal cell contamination occurs in the amniotic fluid specimen. Diagnostic errors can occur due to rare sequence variations, and the performance of this test has not been cleared or approved by the US Food and Drug Administration. It is performed in a CLIA-certified laboratory intended for clinical purposes. The analytic sensitivity and specificity are both 99 percent, but clinical sensitivity is variable and depends on ethnicity.

Test Details

New York Approved