Prion Markers (CJD), CSF (Change effective as of 10/20/25: Refer to 3019310 in the October Hotline)
Also known as: 14-3-3 TAU
Use
May aid in the diagnosis of Creutzfeldt-Jakob disease (CJD) by assessing prion-related markers including qualitative detection of the causative agent via Real‑Time Quaking‑Induced Conversion (RT‑QuIC) and indirect neurodegenerative indicators.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
14‑3‑3 Gamma
ProteinRT‑QuIC
OtherTotal tau Protein
Protein
Result Turnaround Time
8-11 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2 mL (minimum 1 mL)
Minimum Volume
1 mL
Container
ARUP standard transport tubes or other polypropylene tubes
Collection Instructions
Discard first 2 mL of CSF; transfer 2 mL CSF, avoid blood contamination, freeze at –20 °C within 20 minutes of collection.
Patient Preparation
Patient must be 12 years of age or older.
Causes for Rejection
Cloudy or pink specimens may result in partial results; blood contamination may affect results.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | Indefinitely |
Other tests from different labs that may be relevant