Protein S, Functional
Also known as: PROT S F
Use
Protein S, Functional is used for detecting protein S deficiency. This condition can lead to an increased risk of venous thrombosis due to the essential role of protein S in the coagulation pathway as a cofactor to protein C. Accurate assessment of protein S levels aids in diagnosing hereditary thrombophilia and managing patients at risk of thrombotic complications.
Special Instructions
Do not order this test if the individual has been on warfarin therapy in the previous 2-4 weeks, as warfarin can interfere with the results. Refer to specific specimen handling guidelines at aruplab.com for hemostasis/thrombosis sample preparation and shipping.
Limitations
Patients on warfarin therapy may exhibit decreased functional protein S values, and such patients should be off warfarin therapy for at least two weeks prior to testing to ensure accuracy. Heparin therapy or the presence of direct thrombin inhibitors or factor Xa inhibitors may artificially increase protein S levels, leading to misinterpretation of results.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 27822-6
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1.5 mL
Minimum Volume
1 mL
Container
ARUP standard transport tube
Collection Instructions
Collect using a Lt. blue (sodium citrate) tube. Follow specimen handling guidelines for hemostasis/thrombosis.
Storage Instructions
Critical to keep frozen. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Serum, EDTA plasma, clotted or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | 3 months |