Prothrombin Antibody, IgG
Also known as: PROTHROM G
Use
IgG antibodies to prothrombin may be a risk factor for venous or arterial thrombosis in antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies. Results should be interpreted in conjunction with APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.
Special Instructions
Preferred second-line test when seronegative antiphospholipid syndrome (APS) is strongly suspected. Repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.
Limitations
Results should not be used alone for diagnosis. They must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 40595-1
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Causes for Rejection
Contaminated, heat-inactivated, clots, fibrin, gross red blood cells, severely lipemic, severely hemolyzed, or severely icteric specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |