Quetiapine, Serum or Plasma
Also known as: QUETIAP
Use
Quetiapine is an antipsychotic drug used for the treatment of schizophrenia and bipolar disorder. This test measures the quetiapine levels in serum or plasma to monitor therapeutic drug levels and ensure patient adherence to medication. It also helps in optimizing drug therapy by assessing if drug levels fall within the therapeutic or toxic range. The pharmacokinetics of quetiapine are affected by interactions that may alter CYP3A4 metabolism, influencing drug levels.
Special Instructions
The test requires serum or plasma and should be collected into a plain red, lavender (K2 or K3 EDTA), or pink (K2 EDTA) tube. It is important to separate serum or plasma from cells within 2 hours of collection and transfer to an ARUP Standard Transport Tube.
Limitations
This test has been developed by ARUP Laboratories as a Laboratory Developed Test (LDT) and has not been cleared or approved by the FDA. It is performed in a CLIA-certified laboratory for clinical purposes. The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Drug-drug interactions may affect quetiapine levels, leading to changes in pharmacokinetics.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 26776-5
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum or plasma from cells within 2 hours of collection.
Storage Instructions
Refrigerated transport is required.
Causes for Rejection
Whole blood, gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution) tubes are unacceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 2 weeks |
| Frozen | 4 months |