Ribosomal P Protein Antibody
Also known as: RIBPP
Use
The Ribosomal P Protein Antibody test is used to detect central nervous system systemic lupus erythematosus (SLE) or renal involvement in SLE. Autoantibodies reacting with cytoplasmic ribosomes are highly specific for SLE. Ribosomal-P antibodies are found in approximately 12% of SLE patients and in 90% of patients with lupus psychosis, with titers often increasing significantly during active phases of psychosis.
Special Instructions
The test requires serum samples collected in a serum separator tube or red tube. Serum should be separated from cells as soon as possible or within 2 hours of collection.
Limitations
Ribosomal P Protein Antibodies are specific to SLE but may not be present in all cases. Testing is not suitable for use with plasma or other body fluids, and results may be affected by bacterial contamination or severe lipemia. It is important to avoid repeated freeze/thaw cycles as this may impact test results.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 13636-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Collect using a serum separator tube or red tube. Separate serum from cells as soon as possible or within 2 hours of collection.
Storage Instructions
Refrigerate during storage and transport.
Causes for Rejection
Plasma or other body fluids. Bacterially contaminated or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |