Rufinamide, Serum or Plasma
Also known as: RUFIN SP
Use
The Rufinamide, Serum or Plasma test is utilized for therapeutic drug monitoring to optimize drug therapy and monitor patient adherence. It is performed to ensure that the drug concentration remains within the therapeutic range, minimizing the risk of adverse effects. The therapeutic range for Rufinamide is 5-30 µg/mL, with a dose-related range of 3-30 µg/mL for dosages between 800-7200 mg/day.
Special Instructions
Patient specimen should be collected pre-dose (trough) at steady state concentration to ensure accurate monitoring. Specimens must be separated from cells within 2 hours of collection and transferred to an ARUP Standard Transport Tube.
Limitations
The test has not been cleared or approved by the US Food and Drug Administration but is designed for clinical use and performed in a CLIA certified laboratory. Adverse effects from the drug may include somnolence, vomiting, headache, and fatigue, but the toxic concentration of Rufinamide is not well established. Individuals collecting specimens should avoid using gel separator tubes, light blue citrate, or yellow SPS or ACD solution tubes, as these are unacceptable.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 59323-6
- 59323-6
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate from cells ASAP or within 2 hours. Transfer to transport tube.
Patient Preparation
Pre-dose (trough) draw at steady state concentration.
Storage Instructions
Refrigerated.
Causes for Rejection
Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 2 weeks |
| Frozen | 2 weeks |