Sertraline, Serum or Plasma
Also known as: SERTRAL SP
Use
Sertraline is a selective serotonin reuptake inhibitor antidepressant drug indicated for the treatment of major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. This test is used to optimize drug therapy and monitor patient adherence. Sertraline doses range from 50-200 mg/day, resulting in serum concentrations of 30-200 ng/mL. Dosing above 200 mg/day may increase adverse effects like dry mouth, headache, dizziness, fatigue, somnolence, tremor, nausea, and diarrhea. Risk of serotonin syndrome is increased with concomitant use of other serotonergic drugs and may also elevate bleeding risks when used with anticoagulants and NSAIDs.
Special Instructions
Timing of specimen collection is crucial: Pre-dose (trough) draw is required at steady state concentration.
Limitations
The test has not been cleared or approved by the U.S. Food and Drug Administration and was developed with its performance characteristics determined by ARUP Laboratories in a CLIA-certified laboratory, intended for clinical purposes. No additional limitations are noted in the documentation provided.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells within 2 hours of collection. Transfer to tube.
Patient Preparation
Pre-dose (trough) draw at steady state concentration.
Storage Instructions
Refrigerated.
Causes for Rejection
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 2 weeks |
| Frozen | 4 months |