Sex Hormone Binding Globulin
Also known as: SHBG
Use
The Sex Hormone Binding Globulin (SHBG) test is used to evaluate the level of SHBG in the blood. SHBG is a protein produced by the liver that binds tightly to three sex hormones: estrogen, dihydrotestosterone (DHT), and testosterone. This test helps to understand conditions related to abnormal levels of testosterone and estrogen, such as polycystic ovary syndrome, hypothyroidism, and disorders of the liver. It is often used to calculate the free androgen index (FAI) to get a more reliable measure of free testosterone in men and women.
Special Instructions
The specimen for the SHBG test must be collected in a serum separator tube or a green lithium heparin tube. The serum specimen needs to clot completely at room temperature before separation. It is crucial to separate serum or plasma from cells as soon as possible, or within two hours of collection. Subsequently, transfer 0.4 to 0.5 mL of serum or plasma to an ARUP Standard Transport Tube for transportation.
Limitations
The SHBG test is subject to limitations such as potential interference from cross-reacting substances in the serum that may affect the accuracy of the results. Results should be interpreted in conjunction with other clinical and laboratory findings. Grossly hemolyzed specimens and those collected in lavender (EDTA) or pink (K2EDTA) tubes are unacceptable as they may produce inaccurate results. This assay may not be definitive to diagnose or rule out conditions without comprehensive clinical context.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 13967-5
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.4 mL
Container
Serum separator tube or ARUP Standard Transport Tube
Collection Instructions
Allow serum specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube.
Storage Instructions
Refrigerated
Causes for Rejection
Specimens collected in lavender (EDTA) or pink (K2EDTA). Grossly hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 1 week |
| Frozen | 6 months |