Somatic TP53 Mutations in Formalin‑Fixed, Paraffin‑Embedded (FFPE) Tissue
Use
Used to identify TP53 mutations in formalin‑fixed, paraffin‑embedded tumor tissue. TP53 mutation status serves as a prognostic biomarker across multiple tumor types, including lymphoid malignancies.
Special Instructions
Not provided.
Limitations
Specimens with <10% tumor, non‑10% neutral buffered formalin fixation, non‑EDTA decalcifiers, or fine‑needle aspirate smears with <50 tumor cells are unacceptable. Slide(s) will be destroyed during testing and not returned.
Methodology
NGS
Biomarkers
TP53
Gene
Result Turnaround Time
12-14 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Transport block and/or slides in a tissue transport kit (ARUP supply #47808). Resections: 8 unstained 5‑micron slides (min 5). Small biopsies: 15 unstained 5‑micron slides (min 10). NY clients: 7‑10 unstained slides cut at 10 microns.
Causes for Rejection
Less than 10% tumor; fixed in non‑10% neutral buffered formalin; decalcified in non‑EDTA decalcifier; FNA smears with <50 tumor cells.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
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