Special Stain, Thioflavin S
Also known as: THIO S SS
Use
Thioflavin S staining is used as a histochemical stain to visualize amyloid deposits in tissue sections. It is employed in the identification of amyloid plaques, which are associated with neurodegenerative diseases such as Alzheimer's disease. This test is an important tool in neuropathology for the confirmation and diagnosis of amyloid-related conditions.
Special Instructions
The test is performed as a stain and return (technical) service only. Submit electronic request via ARUP Connect™. Use ARUP Anatomic Pathology Form (#32960) with an ARUP client number if you do not have electronic ordering capability.
Limitations
The test is limited to providing visualization of amyloid deposits in formalin-fixed, paraffin-embedded tissue. Specimens submitted with nonrepresentative tissue type or depleted specimens are unacceptable. The interpretation of staining results should be made in conjunction with clinical findings and other pathological data. Frozen specimens are unsuitable for this test.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 10744-1
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
1 slide
Container
Tissue transport kit (ARUP supply #47808)
Collection Instructions
Formalize specimen in 10 percent neutral buffered formalin and paraffin embed. Transport tissue block or 2 unstained (3- to 5-micron thick sections), positively charged slides.
Storage Instructions
Protect paraffin block and/or slides from excessive heat. Room temperature or refrigerated storage is acceptable.
Causes for Rejection
Specimens submitted with nonrepresentative tissue type. Depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |