Succinylacetone, Quantitative, Urine

Casandra

Casandra Test Code AR25844Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2007401CPT Code 83921

Succinylacetone, Quantitative, Urine

Also known as: SUAC URINE

Clinical Use

Order Test

Use

The quantitative measurement of succinylacetone in urine is critical for diagnosing and monitoring individuals with tyrosinemia type 1, a genetic disorder affecting tyrosine metabolism. Accurate quantitation at diagnosis is essential, and organic acids testing is recommended as an initial or concurrent test. Monitoring succinylacetone is vital for patients undergoing therapy for tyrosinemia type 1 to assess treatment effectiveness and adjust as needed. Elevations in succinylacetone are consistent with hepatorenal tyrosinemia, and further evaluation with plasma amino acids and potential genetic analysis is suggested for confirmation.

Special Instructions

First morning urine is preferred for collection. Clinical information, including age, gender, diet, drug therapy, and family history, should be provided to aid in appropriate interpretation of the test results. Submit this information using the Biochemical Genetics Patient History Form available on the ARUP website or by contacting client services.

Limitations

Ambient specimens are unacceptable, and exposure to more than one freeze/thaw cycle can impact the integrity of the specimen. Interpretation may be compromised in specimens with creatinine content below 10 mg/dL, and a more concentrated specimen may be necessary.

Test Details

New York Approved