Thermal Amplitude Test
Also known as: IRL-THERM
Use
The Thermal Amplitude Test is used to determine the clinical significance of cold reacting autoantibodies. It evaluates the thermal amplitude of such antibodies, which is important in assessing their potential impact in clinical settings. Cold autoantibodies with specific reactivity patterns may have clinical significance and can influence transfusion decisions and other medical interventions.
Special Instructions
Prior to ordering the thermal amplitude test, results from the Antibody ID Package (IRL) are required to identify specific antibodies that may interfere with testing. If the Antibody ID Package has not been performed at ARUP within the last 7 days, the test will be added on by ARUP Laboratories and performed, incurring additional charges. Clients must provide patient transfusion history.
Limitations
The test's ability to detect cold autoantibodies is dependent on maintaining the specimen at specific temperatures and processing it timely. Environmental factors and specimen handling can impact the outcomes. Incorrect specimen handling, such as using separator or gel tubes, can lead to unreliable results. Additionally, further testing may be needed depending on antibody complexity, which may incur additional charges.
New York Approved
Methodology
Other
Biomarkers
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
21 mL
Minimum Volume
Not provided
Container
Three 7 ml lavender (K2EDTA) or pink (K2EDTA) tubes
Storage Instructions
Maintain tubes at 37 degrees C until separated from cells. Centrifuge samples to separate plasma from the red blood cells and place in ARUP standard transport tubes.
Causes for Rejection
Separator or gel tubes
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 1 week |
| Frozen | Unacceptable |