Tissue Plasminogen Activator, Antigen
Also known as: TPA AG
Use
The Tissue Plasminogen Activator (tPA) Antigen test determines the quantity of tPA in plasma. It aids in detecting disorders of the fibrinolytic system, though it is not a first-line test for diagnosing inherited thrombotic or bleeding disorders. This test is useful for assessing abnormalities in the fibrinolytic pathway, which can contribute to thrombotic conditions if dysregulated.
Special Instructions
This test is approved for use in New York state. Proper specimen handling is crucial, following the guidelines provided on the ARUP website for hemostasis/thrombosis specimen handling.
Limitations
The test is not recommended as a first-line diagnostic tool for inherited thrombotic or bleeding disorders. It is intended for use in detecting abnormalities in the fibrinolytic system. Improper specimen handling, such as exposure to inappropriate temperatures or conditions, can affect test results.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 5971-7
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Lt. blue (sodium citrate) tube
Collection Instructions
Separate plasma from cells and freeze ASAP. Transfer 1 mL platelet-poor plasma to an ARUP Standard Transport Tube.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Serum, EDTA plasma, clotted or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | 2 months |