Topiramate
Also known as: TOPIR
Use
Topiramate is used in therapeutic drug monitoring to optimize drug therapy and monitor patient adherence. Its pharmacokinetics can vary widely depending on factors like co-medications, age, and renal function. The therapeutic range is typically between 5.0-20.0 ug/mL, but toxic levels are not well established. Monitoring Topiramate levels can help adjust dosage for optimal therapeutic effect while minimizing adverse effects such as somnolence, fatigue, and dizziness.
Special Instructions
Timing of specimen collection is critical. The blood draw should be performed pre-dose (trough) at a steady state concentration. This ensures accurate measurements within the therapeutic range.
Limitations
Test results can be influenced by factors such as variability in pharmacokinetics due to co-medications, age, or compromised renal function. Additionally, while the therapeutic range is defined, toxic levels are not well established, complicating the interpretation of results outside the therapeutic window.
New York Approved
Methodology
Immunoassay (Other)
Biomarkers
LOINC Codes
- 17713-9
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells as soon as possible or within 2 hours of collection. Transfer to the appropriate transport tube.
Patient Preparation
Collect blood pre-dose (trough) at steady state concentration.
Storage Instructions
Refrigerated.
Causes for Rejection
Use of serum or plasma separator tubes, or grossly hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 6 days |
| Refrigerated | 1 week |
| Frozen | 4 weeks |