Tramadol and Metabolite, Quantitative, Serum or Plasma
Also known as: TRAMADOL
Use
This test is used for therapeutic drug monitoring of Tramadol and its metabolite to ensure patient adherence to medication. Monitoring serum levels is crucial because the concentration of the drug in the blood decreases rapidly after administration, necessitating peak level measurement for accurate assessment.
Special Instructions
Peak serum levels should be collected 40 to 90 minutes post-dose to capture the highest concentration for effective monitoring. The test is not performed at ARUP; therefore, each ordered test requires a separate specimen.
Limitations
The test uses High Performance Liquid Chromatography-Tandem Mass Spectrometry, which while precise, requires careful handling of specimens. Separator tubes are unacceptable, and care must be taken to separate from cells within two hours to ensure accurate results. As the test is not FDA approved, performance characteristics were established by NMS Labs.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 12437-0
- 73973-0
Result Turnaround Time
8-11 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate from cells immediately or within 2 hours of collection. Transfer serum to transport tube.
Storage Instructions
Refrigerated. Also acceptable: Room temperature or frozen.
Causes for Rejection
Use of separator tubes.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 weeks |
| Refrigerated | 2 weeks |
| Frozen | 11 months |