Treponema pallidum Antibody, IgG by IFA (CSF)

Casandra

Casandra Test Code AR96343Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0055273CPT Code 86780

Treponema pallidum Antibody, IgG by IFA (CSF)

Also known as: FTA CSF G

Clinical Use

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Use

This test is used in the workup of neurosyphilis by detecting antibodies against Treponema pallidum in cerebrospinal fluid (CSF). It aids in the diagnosis of syphilis by measuring the presence of IgG antibodies. Although a reactive result might be observed in individuals treated in the secondary or latent stage without signs of neurosyphilis, a nonreactive result suggests the absence of neurosyphilis. This test is not FDA cleared or approved but is performed in a CLIA certified laboratory for clinical purposes.

Special Instructions

For CSF specimens, Treponema pallidum (VDRL), Cerebrospinal Fluid with Reflex to Titer is the preferred test. This test is New York state approved and requires the specimen to be refrigerated during transport. The significance of a reactive result is unknown; hence further investigation may be needed if suspicion of neurosyphilis remains.

Limitations

A reactive result does not definitively confirm neurosyphilis as the person may test reactive if they were treated in the secondary or latent stage of syphilis. The test is qualitative and a nonreactive result suggests the absence but not necessarily the complete exclusion of neurosyphilis. Results should be interpreted in conjunction with other clinical findings and tests like Treponema pallidum (VDRL), Cerebrospinal Fluid with Reflex to Titer.

Test Details

New York Approved