Uroplakin II by Immunohistochemistry
Also known as: UROPII IHC
Use
This test offers immunohistochemical staining for Uroplakin II, a protein expressed specifically in urothelial differentiation, useful for assisting in the identification of urothelial carcinoma origin. It is used as a technical “stain and return” service to aid pathologic diagnosis in carcinoma-of-unknown-primary and related contexts. (Evidence: methodology section, note regarding stain and return, test utility implied by IHC use)
Special Instructions
Performed Monday through Friday. It is a stain-and-return technical service only. Ordering recommendations refer to the ARUP Immunohistochemistry Stain Offerings brochure.
Limitations
The test is limited to technical immunohistochemistry staining and does not include interpretation; specimens unsuitable include non-representative tissue type or depleted specimens. Frozen specimens are unacceptable.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 94736-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
2 slides
Container
Tissue block or positively charged slides in tissue transport kit (ARUP supply #47808)
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen; cells must be prepared into a cellblock. Transport tissue block or at least 5 unstained (3‑ to 5‑micron thick) positively charged slides. If sending precut slides, do not oven bake.
Storage Instructions
Room temperature; refrigerated also acceptable; ship in cooled container during summer months.
Causes for Rejection
Non‑representative tissue type; depleted specimens; frozen specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |