Uroplakin II by Immunohistochemistry
Also known as: UROPII IHC
Use
This test offers immunohistochemical staining for Uroplakin II, a protein expressed specifically in urothelial differentiation, useful for assisting in the identification of urothelial carcinoma origin. It is used as a technical “stain and return” service to aid pathologic diagnosis in carcinoma-of-unknown-primary and related contexts. (Evidence: methodology section, note regarding stain and return, test utility implied by IHC use)
Special Instructions
Not provided.
Limitations
The test is limited to technical immunohistochemistry staining and does not include interpretation; specimens unsuitable include non-representative tissue type or depleted specimens. Frozen specimens are unacceptable.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Uroplakin II
Protein
LOINC Codes
- 94736-6 - Tissue block ID Spec
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
2 slides
Container
Tissue block or positively charged slides in tissue transport kit (ARUP supply #47808)
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen; cells must be prepared into a cellblock. Transport tissue block or at least 5 unstained (3‑ to 5‑micron thick) positively charged slides. If sending precut slides, do not oven bake.
Storage Instructions
Room temperature; refrigerated also acceptable; ship in cooled container during summer months.
Causes for Rejection
Non‑representative tissue type; depleted specimens; frozen specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |
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