Venlafaxine and Metabolite, Serum or Plasma
Also known as: VENLAFAXSP
Use
Venlafaxine and its metabolite, o-Desmethylvenlafaxine, are monitored to optimize drug therapy and assess patient adherence. Monitoring is critical to avoid adverse effects such as nausea, vomiting, dizziness, tremor, and blurred vision, which can occur if levels are outside the therapeutic range. This test provides quantitative measurement to ensure concentrations remain within therapeutic ranges and identify potentially toxic levels.
Special Instructions
Ensure pre-dose (trough) collection at steady-state concentration for accuracy. Collect in the appropriate blood collection tube as described, and separate serum or plasma from cells as soon as possible or within 2 hours of collection. Transport the specimen in the recommended conditions.
Limitations
Results may be affected by improper specimen collection or handling procedures, such as failure to separate serum or plasma from cells in a timely manner. Certain conditions may affect drug metabolism and, consequently, the measured levels of venlafaxine and its metabolite. The test has not been cleared or approved by the FDA and is not intended to be the sole criterion for diagnosis or therapeutic decisions. It must be used in conjunction with an evaluation of the patient's clinical condition and other laboratory findings.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 9630-5
- 9628-9
- 62849-5
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate from cells ASAP or within 2 hours of collection.
Patient Preparation
Pre-dose (trough) draw at steady state concentration.
Storage Instructions
Refrigerated transport.
Causes for Rejection
Whole blood; gel separator tubes; light blue (citrate) or yellow (SPS or ACD Solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 weeks |
| Refrigerated | 2 weeks |
| Frozen | 2 weeks |