von Willebrand Factor Multimers
Also known as: VWF MULTI
Use
The von Willebrand Factor Multimers test is used to assist with the diagnosis and subclassification of inherited or acquired von Willebrand disease. The qualitative analysis of von Willebrand factor multimers helps in identifying abnormalities in multimeric distribution, which can be indicative of specific types of von Willebrand disease such as types 2A, 2B, or platelet-type, as well as acquired conditions like cardiac abnormalities, pulmonary hypertension, or myeloproliferative neoplasms. The test should be used in conjunction with other tests like vWF antigen, vWF activity, factor VIII activity, and clinical correlation to provide a comprehensive diagnosis.
Special Instructions
The test requires special specimen collection and handling as per the Hemostasis/Thrombosis Specimens guide. The test is performed Monday through Friday, and separate specimens must be submitted if multiple tests are ordered. It is critical for the plasma to remain frozen during transport. This test is designated as a Laboratory Developed Test (LDT) and is approved by New York state.
Limitations
The von Willebrand Factor Multimers test is a qualitative test and cannot be used in isolation for the diagnosis or subtyping of von Willebrand disease. Multimeric analysis results should be correlated with quantitative results from other assays like vWF antigen and factor VIII activity. Artifacts due to improper sample processing or incorrect specimen types, such as serum, can lead to inaccurate results. To distinguish among qualitative subtypes of von Willebrand disease, local performance of low-dose ristocetin-induced platelet aggregation is also recommended if clinically indicated.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 32217-2
Result Turnaround Time
4-11 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Transfer platelet-poor plasma to an ARUP standard transport tube.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Serum, EDTA plasma, clotted, or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | 3 months |