Chromosome Analysis - Prenatal - CVS
Use
Chromosome Analysis - Prenatal - CVS is a test designed to investigate the chromosome number and structure in chorionic villus sampling (CVS) cells for prenatal diagnosis. This procedure is crucial for detecting chromosomal abnormalities which may indicate underlying genetic disorders. The analysis employs Giemsa banding (G-banding) to visualize metaphase chromosomes. Abnormalities such as aneuploidies and structural rearrangements can be identified, providing essential information for clinical decision-making regarding the pregnancy. It is particularly indicated in cases of prenatal ultrasound anomalies or positive NIPS results, allowing for timely and informed management strategies.
Special Instructions
Fetal cell cultures will be maintained for 7 days post-report issuance. Any additional testing required must be requested within this timeframe, or the fetal cultures will be discarded. This is crucial for ensuring no further diagnostics are missed after the primary analysis.
Limitations
The analysis has limitations, as certain subtle rearrangements (under 5Mb) and low-level mosaicism may not be detected with standard cytogenetic techniques. Also, microdeletions or microduplications cannot be identified using this method; Chromosomal Microarray Analysis might be necessary to further investigate such conditions. Therefore, additional testing should be considered if clinically indicated, as results do not rule out genetic conditions undetectable through cytogenetic analysis.
New York Approved
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
Result Turnaround Time
14 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Fresh)
Volume
15+ mg
Minimum Volume
15 mg
Container
Sterile tissue culture media
Collection Instructions
Collect CVS in sterile tissue culture media.
Causes for Rejection
Specimen cannot be frozen.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hrs |