Chromosome Analysis - Prenatal - CVS

Casandra

Casandra Test Code BA34621Version 1 (DRAFT)

Performing Lab

Lab Baylor GeneticsLab Test ID 8700CPT Codes 88235, 88267, 88280, 88285, 88291

Chromosome Analysis - Prenatal - CVS

Clinical Use

Use

Chromosome Analysis - Prenatal - CVS is a test designed to investigate the chromosome number and structure in chorionic villus sampling (CVS) cells for prenatal diagnosis. This procedure is crucial for detecting chromosomal abnormalities which may indicate underlying genetic disorders. The analysis employs Giemsa banding (G-banding) to visualize metaphase chromosomes. Abnormalities such as aneuploidies and structural rearrangements can be identified, providing essential information for clinical decision-making regarding the pregnancy. It is particularly indicated in cases of prenatal ultrasound anomalies or positive NIPS results, allowing for timely and informed management strategies.

Special Instructions

Fetal cell cultures will be maintained for 7 days post-report issuance. Any additional testing required must be requested within this timeframe, or the fetal cultures will be discarded. This is crucial for ensuring no further diagnostics are missed after the primary analysis.

Limitations

The analysis has limitations, as certain subtle rearrangements (under 5Mb) and low-level mosaicism may not be detected with standard cytogenetic techniques. Also, microdeletions or microduplications cannot be identified using this method; Chromosomal Microarray Analysis might be necessary to further investigate such conditions. Therefore, additional testing should be considered if clinically indicated, as results do not rule out genetic conditions undetectable through cytogenetic analysis.

Test Details

New York Approved