Hematology Profile Panel

Clinical Use

Use

The Hematology Profile Panel is designed to evaluate 302 DNA genes linked to hematologic neoplasms. This panel provides critical, non-invasive insights into various conditions, including myelodysplastic syndrome, acute myeloid leukemia, and VEXAS syndrome. By utilizing advanced genomic and transcriptomic analyses, the test offers timely results that can significantly inform patient management and treatment decisions. It serves as an alternative to more invasive procedures like bone marrow biopsies, ensuring quicker diagnosis and potentially better outcomes for patients with hematologic malignancies.

Special Instructions

Patients are recommended to prepare for testing by consulting their healthcare provider regarding any necessary adjustments to medication or other health-related factors. The laboratory emphasizes the importance of collecting the specimen in a dedicated setting to ensure test integrity and validity. The panel does not require fasting or other specific conditions. Following collection, samples should be handled with care, maintaining the appropriate shipping conditions to preserve sample quality for analysis.

Limitations

The Hematology Profile Panel has certain limitations that should be considered. Although it covers a broad spectrum of genes associated with hematologic neoplasms, there may be mutations outside the panel that could contribute to a patient’s condition. Variants of uncertain significance may also be reported, necessitating further evaluation and confirmation. Additionally, false negatives and positives can occur, which may necessitate additional confirmatory testing. The effectiveness of results can also be influenced by sample quality and the timing of specimen collection. Lastly, continued advancements in genomic medicine mean that guidelines and interpretations will evolve, potentially affecting the relevance of certain findings over time.

Test Details

New York Approved

Methodology

NGS (Targeted)

Biomarkers

2 components

Primary Component • TargetedNext Generation Sequencing • Targeted

Result Turnaround Time

10 days

Specimen

Whole Blood (Fresh)

Volume

5-10 mL

Minimum Volume

5 mL

Container

EDTA tube

Collection Instructions

Draw blood in EDTA (purple-top) tube(s) and send 5-10 mL.

Storage Instructions

Ship at ambient temperature (18-25°C/64-77°F) in an insulated container by overnight courier. Specimen should arrive in the laboratory within 48 hrs of collection. Do not heat or freeze.