HeartCare
Use
HeartCare is a multimodality, non‑invasive surveillance solution for heart transplant recipients. It combines AlloMap (gene-expression profiling reflecting immune activation/quiescence) and AlloSure Heart (donor‑derived cell‑free DNA quantifying graft injury) to provide a personalized assessment of rejection risk and graft health, enabling clinicians to make more informed decisions and potentially reduce the need for invasive biopsies ([caredx.com](https://caredx.com/wp-content/uploads/2021/09/LK-10482-Heartcare-Interpretive-Guide.pdf?utm_source=openai)).
Special Instructions
Not provided.
Limitations
Clinical correlation is required, and AlloMap’s score interpretation depends on timing post‑transplant (e.g., high AlloMap defined as >30 for 2‑6 months or >34 for >6 months post‑transplant). High AlloSure is defined as ≥0.20 %. HeartCare and paired results better identify acute cellular rejection (ACR) than either modality alone, but results must be interpreted within institutional protocols, as performance may vary based on context (e.g., risk of antibody‑mediated rejection) ([caredx.com](https://caredx.com/products-and-services/transplant-services/heart/heartcare/?utm_source=openai)).
Methodology
Composite
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
Not provided
Container
Streck Cell‑Free DNA BCT tube
Collection Instructions
Draw AlloMap specimen first (CPT tube), then AlloSure (Streck cfDNA BCT tubes), from single venipuncture; fill tubes fully, mix by inversion 10×; affix labels lengthwise; store 6–37 °C; ship so specimens arrive within seven days of draw ([caredx.com](https://caredx.com/wp-content/uploads/2022/10/HeartCare_Quick-Draw-Instructions.pdf?utm_source=openai)).
Storage Instructions
Store collected specimens between 6 °C and 37 °C until shipping; arrival at lab within seven days ([caredx.com](https://caredx.com/wp-content/uploads/2022/10/HeartCare_Quick-Draw-Instructions.pdf?utm_source=openai)).