Small-Fiber Dx
Use
The Small-Fiber Dx test provides objective evidence of reduced intraepidermal nerve fiber density (IENFD) to confirm a diagnosis of small fiber neuropathy. It is especially useful for patients who have unexplained neuropathic symptoms and normal nerve conduction studies, helping to diagnose small fiber neuropathy effectively. This test aids clinicians by providing a clear diagnostic pathway for patients with neuropathic symptoms, allowing for targeted treatment approaches.
Special Instructions
Not provided.
Limitations
The test may not detect all cases of small fiber neuropathy, particularly if the nerve fiber density is near the borderline of the normative values. The results are dependent on the adequacy of the biopsy and proper specimen handling during shipping and processing. Normative values are based on age, sex, and biopsy location, which can impact the interpretation of results. Interpretation requires specialized knowledge to differentiate neuropathy from other dermatologic conditions that may mimic its symptoms.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
Result Turnaround Time
0 days
Related Documents
For more information, please review the documents below
Specimen
Skin
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Collect three small skin biopsies using the provided test kit. Ensure the sample is handled and shipped at room temperature.
Causes for Rejection
Improper collection or shipment, inadequate sample volume, or improper labeling may lead to sample rejection.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Specimen should be shipped at room temperature to ensure quality. |