Casandra Test Code FM51862Version 1 (DRAFT)
FoundationOne®RNA
Use
FoundationOne RNA is an RNA sequencing test designed to detect gene fusions and rearrangements across 318 cancer-related genes in all solid tumors. It offers a comprehensive approach to identify actionable targets for personalized therapy, especially important in cancers like NSCLC, where RNA sequencing is recommended by guidelines.
Special Instructions
Not provided.
Limitations
FoundationOne RNA has not been cleared or approved by the FDA. A negative result does not rule out the presence of a fusion or rearrangement. Genomic findings are not prescriptive or conclusive for the labeled use of any specific therapeutic product.
Methodology
Biomarkers
Mutation (315 genes)
ABCB1ABL1ABL2ACSL6AFF1AFF4AKT1AKT2AKT3ALKAPCARARHGAP26ARHGDIAARID1AARID1BASXL1ATICATMATRAXLB2MBAP1BCL10BCL11BBCL2BCL3BCL6BCORBCRBRAFBRCA1BRCA2BRD3BRD4BRIP1BTG1BTKCAMTA1CBFA2T3CBFBCBLCCND1CCND2CCND3CCNE1CD19CD274CD28CD38CD74CDH1CDK4CDK6CDKN2ACDKN2BCEBPACICCIITACLDN18CLDN3CLTCCNTRLCOL1A1CREB3L1CREB3L2CREBBPCRLF2CSF1CUX1CXCR4CYLDDDIT3DDR1DDR2DDX10DEKDHHDIRC2DLC1DNMT3ADUSP22EBF1EGFREIF4A2ELF4ELLELNEML4EP300EPOREPS15ERBB2ERBB3ERGESR1ETS1ETV1ETV4ETV5ETV6EWSR1FBXW7FEVFGFR1FGFR1OPFGFR2FGFR3FGFR4FGRFLI1FLT3FOSFOSBFOXO1FOXO3FOXO4FOXP1FUSGAS7GLI1GLIS2HDAC10HERPUD1HEY1HIP1HLFHMGA1HMGA2IGHIGKIGLIKZF1IKZF2IKZF3INSRIRF4ITKJAK1JAK2JAK3JAZF1KAT6AKIF5BKITKMT2ALATS2LCP1LMNALMO1LMO2LPPLTKMAFMAFBMALT1MAML2MAP3K7MAP3K8MAST1MDS2MECOMMEF2CMEF2DMEN1METMGMTMKL1MKL2MLF1MLH1MLLT1MLLT10MN1MNX1MSH2MSH6MSI2MSMBMTAPMTCP1MYBMYCMYH11NAB2NDE1NFKBIANINNOTCH1NOTCH2NOTCH3NOTCH4NPM1NR4A3NRASNRG1NRG2NSD1NTRK1NTRK2NTRK3NUMA1NUP214NUP98NUTM1NUTM2AP2RY8PALB2PAX3PAX5PAX7PBX1PBX3PDCD1LG2PDGFBPDGFDPDGFRAPDGFRBPHF1PICALMPIK3CAPIK3R1PIK3R2PKN1PLAG1PMS2PPARGPRDM16PRKACAPRKCAPRKCBPRMT5PTCH1PTENRAF1RARARASGRF1RB1RELARETRHOHROS1RPS6KB1RSPO2RSPO3RUNX1RUNX1T1SDHASDHBSDHCSDHDSEC31ASEPT5SEPT6SEPT7SETSH3GL1SLC45A3SMAD2SMAD4SMARCB1SNX29SRCSS18SSX1SSX2SSX4STAT6STILSTK11SYKTAF15TAL1TAL2TBL1XR1TCF3TCF4TCL1ATCL6TECTERTTET1TET2TFE3TFEBTFGTFPTTHADATLX1TLX3TMPRSS2TOP1TP53TP63TPM3TPM4TRIM24TRIP11TSC1TSC2TTLTYK2USP6VHLWHSC1WHSC1L1WT1WWTR1YAP1YWHAEZAP70ZBTB16ZMYM2ZNF384ZNF750
Result Turnaround Time
Related Documents
For more information, please review the documents below
Other tests from different labs that may be relevant
Volume
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