Slice – Single Gene (1 gene)

Casandra

Casandra Test Code GE49515Version 1 (DRAFT)

Performing Lab

Lab GeneDxLab Test ID TG70

Slice – Single Gene (1 gene)

Clinical Use

Use

The Slice – Single Gene (1 gene) test allows selective examination of one gene of interest using next-generation sequencing on custom-selected gene lists, enabling confirmation of clinical diagnoses, genetic counseling, and recurrence‑risk assessment. Reported variants include pathogenic, likely pathogenic, and variants of uncertain significance (VUS); heterozygous VUS in autosomal recessive genes may be reported separately; benign or likely benign variants are excluded.

Special Instructions

Changes to the gene list must be made by contacting GeneDx directly at [email protected]. The test requires prior full exome analysis (XomeDx®). Ordering uses Test Code TG70. Approved Slice ID appears but may vary. Requires submission of specimen and informed consent per GeneDx ordering procedures.

Limitations

Only the gene selected and included in the approved gene list will be analyzed. Genes with poor coverage, homologous regions, technical sequencing issues, mitochondrial genes, non‑coding, regulatory or deep intronic regions are not suitable for this method. Coverage data is average; actual coverage for requested genes may vary. Only CNVs involving ≥3 exons may be detected.

Test Details