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Spinocerebellar Ataxia Type 2 (SCA2) is a slowly progressive neurodegenerative disorder characterized by ataxia, dysarthria, dysphagia, oculomotor dysfunction (including nystagmus, slow saccadic eye movements, ophthalmoparesis), tremor, peripheral neuropathy, dystonia or chorea, dementia, and occasionally parkinsonism. Infantile-onset neurodevelopmental features including developmental delay, hypotonia, seizures, and cerebellar atrophy have also been reported. SCA2 is inherited in an autosomal dominant manner, caused by expansion of a CAG trinucleotide repeat in exon 1 of the ATXN2 gene, with molecular genetic testing detecting expansions in >99% of affected individuals.