5′ Nucleotidase
Use
5′ nucleotidase is used to investigate the origin of increased serum alkaline phosphatase. It is a liver-related enzyme used to work up cholestatic/biliary obstruction. It parallels the increases of alkaline phosphatase and leucine aminopeptidase in hepatobiliary diseases, but is not usually elevated in skeletal disorders such as Paget disease of bone. It is increased with metastatic neoplasia in liver and in primary biliary cirrhosis, biliary obstruction from calculi and tumor.
Special Instructions
Not provided.
Limitations
The test may not provide a definitive diagnosis but can aid in the identification of liver-related abnormalities. It should be noted that 5′ nucleotidase levels are not usually elevated in skeletal disorders, limiting its utility in non-hepatobiliary-related conditions. Additionally, the test results should be interpreted in conjunction with other clinical findings and laboratory tests.
Methodology
Automated Analyzer
Biomarkers
LOINC Codes
- 1690-7
- 1690-7
Result Turnaround Time
6-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
Red-top tube or gel-barrier tube for serum
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |