Acetylcholine Receptor (AChR) Antibodies, Complete Profile
Also known as: Acetylcholine Receptor Complete Antibody Profile, Myasthenia Gravis Evaluation Complete Profile
Use
Test for the laboratory diagnosis of myasthenia gravis (MG)
Special Instructions
The test includes the assessment of acetylcholine receptor-binding, receptor-blocking, and receptor-modulating antibodies. It utilizes a combination of radioimmunoassay (RIA) and flow cytometry techniques to provide comprehensive diagnostic information. Suitable specimen is serum separated from cells within 45 minutes of collection.
Limitations
This test has not been cleared or approved by the Food and Drug Administration. In rare cases, AChR antibodies can be found in patients with other autoimmune disorders or with thymoma without MG. The specific autoantibody cannot be identified in up to 10 percent of patients with MG. Autoantibody levels may not correlate with disease severity, although serial antibody titers in individual patients tend to correlate with disease status. Striational antibodies are associated with the late-onset MG subgroup and are rarely found in AChR antibody-negative MG.
Methodology
Other
Biomarkers
LOINC Codes
- 20427-1
- 11034-6
- 11561-8
- 99062-2
Result Turnaround Time
3-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within 45 minutes of collection. Send serum in plastic transport tube.
Storage Instructions
Refrigerate (cool pack).
Causes for Rejection
Improper labeling; gross microbial contamination; specimen contaminated with anticoagulants; chylous serum; plasma specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 13 days |
| Refrigerated | 13 days |
| Frozen | 13 days |