Adrenocorticotropic Hormone (ACTH), Plasma, Two Specimens
Use
The Adrenocorticotropic Hormone (ACTH) test helps in the evaluation of patients suspected of having abnormal cortisol levels. ACTH (a peptide hormone) stimulates the production of cortisol, a key hormone in the body's stress response. This test is valuable in diagnosing conditions such as Cushing's syndrome or Addison's disease by measuring the amount of ACTH in the blood to assess pituitary gland function. The panel involves multiple specimen collections to determine baseline and post-treatment ACTH levels, offering insights into how cortisol production varies in response to physiological stimuli or treatment.
Special Instructions
Instructions for suppression or stimulation tests involving ACTH measurement are available in the Endocrine Appendix of the LabCorp Directory of Services. This test requires multiple tubes to be drawn at different time points. If no treatment is administered after the first sample collection, the panel should not be used. Confirm with the clinician before ordering this series. Patients should halt biotin supplementation at least 72 hours before sample collection due to potential test interference.
Limitations
This test may show interference when the sample is collected from someone consuming a high dose of biotin. As such, it's crucial to ask patients about their biotin use and advise them to stop supplementation three days before the test. The ACTH measurement is valid only at specific times, typically between 7 and 10 AM. Additionally, any ongoing treatment can affect hormone levels, thereby altering test results. For valid interpretation, proper timing and handling protocols must be followed.
Methodology
Other
Biomarkers
LOINC Codes
- 42598-3
- 46963-5
- 39564-0
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
This panel requires multiple tubes to be drawn. Collect an initial baseline tube, administer treatment, then collect more tubes post-treatment. Do not collect without prior clinician consultation if no treatment follows the first draw.
Patient Preparation
Patients should stop biotin consumption at least 72 hours before sample collection.