Allergen Profile, Brazil Nut, IgE With Component Reflexes
Use
The measurement of specific immunoglobulin E (IgE) to individual components of an allergen, either purified native or recombinant, is referred to as component resolved diagnosis (CRD).1-5 This approach represents an improvement over traditional measurement of IgE to allergen extracts that contain a mixture of proteins. The pattern of specific IgE reactivity to component allergens can predict which patients are at higher risk for systemic allergic reactions versus those who are sensitized but clinically tolerant. CRD can also be used to predict which patients are at risk for more severe reactions and which patients are likely to have milder symptoms.
Special Instructions
Not provided.
Limitations
Although the use of component IgE testing may enhance the evaluation of potentially allergic individuals over the use of whole extracts alone, it cannot yet replace clinical history or oral food challenge in most cases. Clinical history, patient's age, and presence of comorbidities (such as atopic dermatitis) must be incorporated into the diagnostic determination. If a food is tolerated in the patient's diet on a regular basis, detectable food-specific IgE does not confer allergy to that food. If allergy to a specific food is suspected based on clinical history, an undetectable food specific IgE does not exclude allergy to that food.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 6050-9
- 8251-1
- 6050-9
- 64963-2
Result Turnaround Time
3-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 18 months |