Allergen Profile, Brazil Nut, IgE With Component Reflexes

Casandra

Casandra Test Code LC11833Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 603972CPT Code 86003

Allergen Profile, Brazil Nut, IgE With Component Reflexes

Clinical Use

Use

The measurement of specific immunoglobulin E (IgE) to individual components of an allergen, either purified native or recombinant, is referred to as component resolved diagnosis (CRD).1-5 This approach represents an improvement over traditional measurement of IgE to allergen extracts that contain a mixture of proteins. The pattern of specific IgE reactivity to component allergens can predict which patients are at higher risk for systemic allergic reactions versus those who are sensitized but clinically tolerant. CRD can also be used to predict which patients are at risk for more severe reactions and which patients are likely to have milder symptoms.

Special Instructions

Not provided.

Limitations

Although the use of component IgE testing may enhance the evaluation of potentially allergic individuals over the use of whole extracts alone, it cannot yet replace clinical history or oral food challenge in most cases. Clinical history, patient's age, and presence of comorbidities (such as atopic dermatitis) must be incorporated into the diagnostic determination. If a food is tolerated in the patient's diet on a regular basis, detectable food-specific IgE does not confer allergy to that food. If allergy to a specific food is suspected based on clinical history, an undetectable food specific IgE does not exclude allergy to that food.

Test Details