Allergen Profile, Egg White, IgE With Component Reflexes
Use
The measurement of specific immunoglobulin E (IgE) to individual components of an allergen, either purified native or recombinant, is referred to as component resolved diagnosis (CRD).1-4 This approach represents an improvement over traditional measurement of IgE to allergen extracts that contain a mixture of proteins. The pattern of specific IgE reactivity to component allergens can predict which patients are at higher risk for systemic allergic reactions versus those who are sensitized but clinically tolerant. CDR can also be used to predict which patients are at risk for more severe reactions and which patients are likely to have milder symptoms.
Special Instructions
Not provided.
Limitations
Allergen-specific IgE assays do not provide absolute positive and negative predictive values for allergic diseases. Diagnostic determinations must include clinical history. While component resolved IgE testing improves evaluation over whole extracts, it cannot replace clinical histories and oral food challenges in most cases. Sensitization to unidentified determinants not in extracts or components may cause symptoms in rare instances.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
Gal d 1
ProteinGal d 2
Protein
LOINC Codes
- 6106-9 - Egg White IgE Qn
- 8251-1 - Service Cmnt-Imp
- 6106-9 - Egg White IgE Qn
- 7556-4 - Ovalb IgE Qn
- 7557-2 - Ovomucoid IgE Qn
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 18 months |
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