Allergen Profile With Component Reflexes, Respiratory–Area 1

Casandra

Casandra Test Code LC64828Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 606995CPT Codes 82785, 86003

Allergen Profile With Component Reflexes, Respiratory–Area 1

Clinical Use

Use

Detect possible allergic responses to various substances in the environment (see Test Includes) and evaluate for hay fever, asthma, atopic eczema, and respiratory allergy. The quantitative allergen-specific IgE test is indicated (1) to determine whether an individual has elevated allergen-specific IgE antibodies; (2) if specific allergic sensitivity is needed to allow immunotherapy to be initiated; (3) when testing individuals for agents that may potentially cause anaphylaxis; (4) when evaluating individuals who are taking medication (eg, long-acting antihistamines) that may interfere with other testing modalities (eg, skin testing); (5) if immunotherapy or other therapeutic measures based on skin testing results have not led to a satisfactory remission of symptoms; (6) when an individual is unresponsive to medical management where identification of offending allergens may be beneficial.

Special Instructions

If dog IgE is ≥0.35 kU/L, further testing on specific dog allergens (Can f 1 to Can f 6) will be performed. Similarly, if cat IgE is ≥0.35 kU/L, further tests on specific cat allergens (Fel d 1, Fel d 2, Fel d 4, Fel d 7) will be conducted. The test includes various region-specific allergens and total Immunoglobulin E.

Limitations

Results may vary due to potential interference from medications (e.g., antihistamines). The quantitative test results need to be interpreted in the context of the clinical picture as false positives or exaggerated levels can occur. Conditions such as unresponsive dermatitis not correlated to specific allergens might not reflect in IgE levels. The test may not comprehensively cover all potential environmental allergens, and ongoing environmental changes might introduce new allergens not covered by the test.

Test Details