Allergen Profile With Component Reflexes, Respiratory–Area 11
Use
Detect possible allergic responses to various substances in the environment (see Test Includes) and evaluate for hay fever, asthma, atopic eczema, and respiratory allergy. The quantitative allergen-specific IgE test is indicated (1) to determine whether an individual has elevated allergen-specific IgE antibodies; (2) if specific allergic sensitivity is needed to allow immunotherapy to be initiated; (3) when testing individuals for agents that may potentially cause anaphylaxis; (4) when evaluating individuals who are taking medication (eg, long-acting antihistamines) that may interfere with other testing modalities (eg, skin testing); (5) if immunotherapy or other therapeutic measures based on skin testing results have not led to a satisfactory remission of symptoms; (6) when an individual is unresponsive to medical management where identification of offending allergens may be beneficial.
Special Instructions
The test includes reflex testing for specific animal dander allergens if the initial IgE level for dog or cat dander exceeds a threshold of 0.35 kU/L. The reflexes will test for detailed components like Can f and Fel d proteins, helping distinguish between sensitization to specific molecular allergens, which may guide treatment decisions.
Limitations
The results should be interpreted in the context of a patient's clinical history, and while the use of component IgE testing may enhance the evaluation of potentially allergic individuals over the use of whole extracts alone, it does not replace comprehensive clinical assessment. Results may be affected by recent treatments or the presence of cross-reacting proteins from related allergens, leading to false positives.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 19113-0
- 8251-1
- 6096-2
- 6095-4
- 6833-8
- 6098-8
- 6041-8
- 6265-3
- 6078-0
- 6212-5
- 6075-6
- 6025-1
- 6020-2
- 7155-5
- 15284-3
- 6178-8
- 6189-5
- 6109-3
- 6192-9
- 6090-5
- 6281-0
- 6085-5
- 6183-8
- 6234-9
- 7604-2
- 6244-8
- 6181-2
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3.5 mL
Minimum Volume
Not provided
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Inadequate labeling; gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 18 months |
