Allergen Profile With Component Reflexes, Respiratory–Area 19

Casandra

Casandra Test Code LC54288Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 606985CPT Codes 82785, 86003

Allergen Profile With Component Reflexes, Respiratory–Area 19

Clinical Use

Use

Detect possible allergic responses to various substances in the environment (see Test Includes) and evaluate for hay fever, asthma, atopic eczema, and respiratory allergy. The quantitative allergen-specific IgE test is indicated (1) to determine whether an individual has elevated allergen-specific IgE antibodies; (2) if specific allergic sensitivity is needed to allow immunotherapy to be initiated; (3) when testing individuals for agents that may potentially cause anaphylaxis; (4) when evaluating individuals who are taking medication (eg, long-acting antihistamines) that may interfere with other testing modalities (eg, skin testing); (5) if immunotherapy or other therapeutic measures based on skin testing results have not led to a satisfactory remission of symptoms; (6) when an individual is unresponsive to medical management where identification of offending allergens may be beneficial.

Special Instructions

The reflexive component testing is triggered when IgE levels for cat or dog allergens exceed certain thresholds. If Dog IgE ≥0.35 kU/L, an in-depth IgE analysis for Can f 1, Can f 2, Can f 3, Can f 4, Can f 5, and Can f 6 is conducted. Similarly, if Cat IgE ≥0.35 kU/L, reflex testing is performed for Fel d 1, Fel d 2, Fel d 4, and Fel d 7. Test results should be interpreted considering the patient's clinical history.

Limitations

The results of the allergen-specific IgE test should be integrated with a patient's comprehensive clinical evaluation, as the use of component IgE testing generally enhances the evaluation over using whole extracts alone. Cross-reactivity between various allergens can pose interpretation challenges. Molecular similarity might cause sensitization to multiple components, complicating the diagnosis of primary sensitizers. Although the results can help diagnose allergies and guide therapeutic measures, they offer limited value in isolation without considering clinical symptoms.

Test Details