Allergen Profile With Component Reflexes, Respiratory-Area 2

Casandra

Casandra Test Code LC25452Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 607111CPT Codes 82785, 86003

Allergen Profile With Component Reflexes, Respiratory-Area 2

Clinical Use

Use

Detect possible allergic responses to various substances in the environment (see Test Includes) and evaluate for hay fever, asthma, atopic eczema, and respiratory allergy. The quantitative allergen-specific IgE test is indicated (1) to determine whether an individual has elevated allergen-specific IgE antibodies; (2) if specific allergic sensitivity is needed to allow immunotherapy to be initiated; (3) when testing individuals for agents that may potentially cause anaphylaxis; (4) when evaluating individuals who are taking medication (eg, long-acting antihistamines) that may interfere with other testing modalities (eg, skin testing); (5) if immunotherapy or other therapeutic measures based on skin testing results have not led to a satisfactory remission of symptoms; (6) when an individual is unresponsive to medical management where identification of offending allergens may be beneficial.

Special Instructions

The test includes measurement of both standard allergens and additional components if reflex criteria are met. For example, if IgE to Dog Dander or Cat Dander exceeds 0.35 kU/L, component-specific reflex tests for specific proteins will be performed. This approach helps in identifying specific allergen components responsible for sensitization and providing comprehensive allergy assessment.

Limitations

The test relies on the detection of IgE antibodies and may not fully capture every allergy aspect as some reactions could be non-IgE mediated. Results should be interpreted in the context of the patient’s clinical history, and additional interferences from other conditions or treatments should be considered. Variability in allergen exposure and inherent differences in individual responses can affect results; therefore, a negative result does not entirely rule out the possibility of an allergic reaction. Moreover, cross-reactivity among different allergens, especially among those in related species, could complicate diagnostic specificity.

Test Details